Blood Clots Could Be the Root Reason for All Coronary heart Illness

On this interview, repeat visitor Dr. Malcolm Kendrick, a board-certified household doctor and creator of the ebook, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” opinions the underlying mechanisms for coronary heart illness, which for the final century has been the main reason for loss of life within the U.S.

Of all of the books he’s written, that is my favourite, because it goes into nice element, providing you with the organic understanding of the method of atherosclerosis resulting in coronary heart assaults and strokes. He additionally has strong methods for reducing your heart problems threat.

By the way, when you perceive the illness course of, then you too can perceive how each COVID-19 and the COVID jab can contribute to coronary heart illness. When requested why he’s taken such an curiosity in coronary heart illness, Kendrick replies:

“After I was coaching as a scholar in drugs, Scotland had the very best fee of coronary heart illness on the planet. Early on the reply for why was, ‘Oh, effectively, it is as a result of we have now such horrible food regimen, and we eat garbage meals like deep fried Mars bars.’

So, you eat an excessive amount of saturated fats, the saturated fats will get become ldl cholesterol in your bloodstream, after which it’s absorbed into arteries and kinds narrowings and thickenings, which all sounds believable in case you do not give it some thought too arduous.

However I additionally occur to go to France quite a bit, and what I observed about France was, they eat a number of saturated fats. They eat extra, the truth is, than anybody else in Europe, and definitely greater than Scotland. So, [this saturated fat] speculation definitely did not work for the French. They’ve the very best saturated fats consumption in Europe and lowest fee of coronary heart illness, and this has been the case for many years.

If you happen to took all the danger components for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had barely [higher risk], based on standard pondering. However, the truth is, that they had one-fifth [the rate among age-matched men].

So, I assumed, that is fascinating. It does not make a lot sense based on what we’re advised. Then whereas I used to be in medical faculty, a tutor in cardiology stated … LDL can not cross the endothelium. On the time, I did not know what LDL was, nor did I do know what the endothelium was, but it surely sounded essential.

She had been taking a look at coronary heart illness as a distinct course of for many years … So, I believe that is actually the place I obtained began. When you begin questioning what the issue is, you find yourself questioning an increasing number of and also you begin pondering, gosh, that is simply nonsense, is not it? This entire speculation is simply nonsense. So, I began choosing it aside.”

The Thrombogenic Speculation

“The Clot Thickens” is Kendrick’s effort to elucidate another speculation for what really causes coronary heart illness. If it’s not saturated fats and ldl cholesterol, what’s it? In 1852, a Viennese researcher, Karl von Rokitansky, developed what he known as the encrustation speculation of coronary heart illness.

As we speak, this speculation has been renamed the thrombogenic speculation. ‘Thrombo’ stands for thrombosis, i.e., blood clots, and ‘genesis’ means the reason for, or the beginning of. So, the thrombogenic speculation is that blood clots are the essential pathology that causes all coronary heart illness.

In a nutshell, when a blood clot kinds in your artery wall, which might occur for quite a lot of causes, it would sometimes be lined over and dissolved. An issue arises, nonetheless, if the blood clot isn’t absolutely eradicated and one other blood clot kinds in the identical ‘weak’ space. This then turns into what’s conventionally known as atherosclerotic plaque.

“The atherosclerotic plaque is principally a buildup of blood clot, restore, blood clot, restore, blood clot, restore,” Kendrick explains. “If the blood clotting course of is quicker than the restore course of, you have got a plaque that regularly grows and finally thickens the artery wall till it narrows sufficiently that the ultimate blood clot, on prime of the present plaque, is the factor that may trigger a coronary heart assault or stroke …

If you happen to lower via the plaque and take a look at it, it virtually seems to be like tree rings. You’ll be able to see there’s been a clot, restore, clot, restore, clot, restore, clock, restore over time.

It’s extensively accepted {that a} blood clot forming on an current plaque will trigger the plaque to develop in measurement. You will discover 10,000 papers saying that that is the case. What the mainstream will not settle for is {that a} blood clot on a wholesome artery wall can provoke the entire course of.

So, to an extent, all I am saying to folks is, effectively, we all know blood clots trigger the ultimate occasion. We all know blood clots trigger plaques to develop. Why will not you settle for that blood clots are the factor that begins it within the first place? As a result of then we have now one course of during, and it is smart, as a result of it suits with what you possibly can see.”

As famous by Kendrick, the traditional view is that low-density lipoprotein or LDL will get into the artery wall the place it initiates plaque formation. It then, inexplicably, stops initiating plaque, and the plaque continues to develop via the addition of repeated clots.

Nevertheless, Kendrick says, when you begin drilling down into the ldl cholesterol, aka LDL speculation, the entire thing begins to disintegrate. LDL merely can not clarify the illness development. But regardless of the numerous holes within the idea, the concept LDL causes coronary heart illness is touted as an absolute, incontrovertible fact.

What’s the Mechanism?

With a purpose to justify a speculation, you could have a mechanism of motion. When you perceive the mechanism of the particular illness course of, then you possibly can put the puzzle items collectively. Kendrick begins his clarification:

“Your blood vessels are lined with endothelial cells, a bit like tiles on a wall. Endothelial cells are additionally lined themselves in a factor known as glycocalyx. If you happen to attempt to decide up a fish, it’s going to slip via your fingers; it’s totally slippery. The explanation it is slippery is as a result of it’s lined in glycocalyx and the glycocalyx is extremely slippery. It is nature’s Teflon.

So principally, in our case, the glycocalyx [is inside] our blood vessels, to permit the blood to journey via with out it sticking, with out harm occurring. So, you have got this type of damage-repellent layer on prime of your endothelial cells.

Now, if that layer is broken, after which the endothelial cell itself beneath is broken, then the physique will say, ‘Oh, we have harm to a blood vessel, we should have a blood clot there as a result of we might bleed out.’ So, a blood clot kinds on the realm of harm, and instantly stops [the bleeding].”

The blood clot doesn’t simply carry on rising and rising. If it did, you’d die anytime you had a blood clot. As an alternative, when a clot kinds, different processes step in to stop it getting too large, which is why each blood clot doesn’t trigger a stroke or coronary heart assault. As soon as the clot has stabilized, and has been shaved down, the realm is roofed over by endothelial progenitor cells, made within the bone marrow, that float round in your blood stream.

When a progenitor cell finds an space that has been broken, it attaches itself to that space, together with others, forming a brand new endothelial layer. The remaining blood clot is now mendacity ‘inside’ the artery wall itself. So, principally, it’s the restore course of that may result in plaque buildup throughout the artery wall. In time, if harm outstrips restore, this may slender the artery and cut back blood stream.

What Damages Endothelial Cells?

The query is, what can harm the endothelium within the first place? Right here, Kendrick makes use of the SARS-CoV-2 mechanism for instance:

“The COVID virus enters endothelial cells via the ACE2 receptor. It prefers endothelial cells as a result of they have ACE2 receptors on them. It will get into the endothelial cell and begins replicating, then bursts out, damaging the cell. Bingo, you’ve obtained an space of harm.

In fact, added to this, when cells have viruses inside them, they ship out misery indicators to the immune system saying, ‘I have been contaminated, come and kill me,’ and so the immune system begins to have a go on the endothelial cells. Because of this you may get an issue, as a result of the endothelial cells are being broken and stripped off.

Blood clotting happens on the factors of harm and hey, presto, you are having clotting, you are having strokes, you are having coronary heart assaults, which is the factor that folks at first could not perceive [about COVID-19]. But it’s totally clear that what’s occurring is you have obtained harm to the endothelial cells.

Clearly, you and I each know that in case you get a [COVID jab], the cells are triggered to provide the spike protein, and these cells are sending out misery messages saying, ‘I’m contaminated.’ It’s a must to be very cautious if you wish to stick one thing into cells that then says to the immune system, ‘Please come and destroy me,’ as a result of that is what the immune system goes to do.

However shifting on from that, what different factor may cause endothelial harm? The reply is issues like smoking. Smoke particles get out of your lungs, they go into your blood vessels they usually trigger harm … You smoke one cigarette and an entire bunch of microparticles seem in your bloodstream, which implies endothelial cells are dying.

Fortunately as endothelial cells die, one other message is distributed to the bone marrow saying, we want extra endothelial cells and it stimulates endothelial progenitor cell manufacturing. These endothelial progenitor cells rush round overlaying over the areas of harm.

Some people who smoke have sufficient restore happening and while you’re youthful, it is okay. As you become older and your restore programs start to fail a bit, cigarette smoking turns into an increasing number of of an issue.”

Different issues that may trigger endothelial harm embody:

Repairing the Glycocalyx

As defined by Kendrick, the glycocalyx layer resembles a garden, with slippery filaments that stick up. Inside this glycocalyx layer you have got nitric oxide synthase (NOS), which produces nitric oxide (NO), and you’ve got NO itself, in addition to quite a lot of different anticoagulant proteins. The glycocalyx is definitely a potent anticoagulant layer, so it stops blood clots forming. If glycocalyx is broken, your threat of blood clotting will increase.

“It’s a really sophisticated layer,” Kendrick says. “It is like a jungle stuffed with issues that say, ‘Do not stick with this, steer clear of this.’” Inside it, you even have albumin, protein advanced produced by the liver. Albumin incorporates the proteins that assist preserve and restore the glycocalyx. A reality that almost all medical doctors are unaware of is that, in case you have a low albumin degree, you are considerably extra more likely to die of coronary heart illness.

The excellent news is that whereas the glycocalyx layer might be quickly destroyed, it may also be quickly repaired. (Experiments have proven that in an space the place the glycocalyx has been fully stripped off, it may be fully repaired in a single second.) Dietary supplements like chondroitin sulfate and methylsulfonylmethane (MSM) might be useful on this regard.

“If you happen to attempt to clarify that via the LDL mechanism, it simply does not work,” Kendrick says. “They’ve found that in case you give chondroitin sulfate as a complement — which usually is for arthritis and stuff like that — it reduces the danger of coronary heart illness fairly significantly. How do you clarify that? Properly, you possibly can clarify that since you’re defending your glycocalyx.

These are the kind of issues that make no sense in case you like trying on the standard concepts of coronary heart illness, however are instantly and simply defined in case you say, ‘Now we have to maintain our glycocalyx wholesome and we have now to maintain our endothelial cells beneath them wholesome.

In any other case they are going to be broken and stripped off, after which we’ll get a blood clot, and if we hold getting blood clots at that time, we’ll find yourself with a plaque and finally one of many blood clots on that plaque will kill you from a coronary heart assault or a stroke.”

Blood Circulate Restriction Coaching

A way of life technique that may assist restore endothelial harm is blood stream restriction (BFR) coaching. In response to BFR, your physique produces vascular endothelial progress issue (VEGF), which acts as “fertilizer” for the endothelium. You’ll be able to study the ins and outs of BFR in my free BFR report. VEGF additionally induces the synthesis of nitric oxide (NO), a potent vasodilator, and it stimulates endothelial progenitor cells.

“NO protects the endothelium. It’s anticoagulant — essentially the most potent anticoagulant we have now within the physique. It’s actually the magic molecule for cardiovascular well being,” Kendrick says.

“At one time NO was referred to as Endothelial Derived Rest Issue (EDRF) NO was one thing nobody believed might presumably exist within the human physique. NO is definitely a free radical. Everybody says free radicals are terribly damaging and unhealthy.

To that I reply, ‘Properly, you might want to know that the chemical that’s the single most essential protecting chemical within the physique for the cardiovascular system is an extremely free radical known as nitric oxide.”

Some anticancer medication are designed to dam VEGF, because the tumor wants angiogenesis — which is the creation of recent blood vessels which might be required to supply ample ‘vitamins’ With out these new blood vessels, the tumor dies off. Sadly, in case you block VEGF, you additionally block NO, which then raises your threat for coronary heart illness.

“These medication have been virtually faraway from the market,” Kendrick says, “as a result of regardless of their anticancer exercise, they have been procardiovascular illness to fairly a scary diploma.

[That’s why], if you’re given bevacizumab or Avastin as an anticancer drug, they now provide you with angiotensin changing enzyme inhibitors (ACE inhibitors), that are blood stress reducing tablets, and ACE inhibitors have a selected affect on bradykinin, which will increase NO synthesis.”

Methods to Decrease Your Thrombotic Threat

In his ebook, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” Kendrick opinions many alternative methods that may decrease your illness threat. Right here’s a short-list of examples lined in far higher depth within the ebook, in addition to a few of my very own suggestions that I deliver up within the interview: