Aspirin is a staple in drugs cupboards worldwide, identified primarily for its pain-relieving and anti inflammatory properties. Nevertheless, latest analysis is shedding gentle on a probably game-changing function for this frequent treatment: most cancers prevention and therapy.1
Whereas aspirin’s anticancer properties have been hinted at in varied research through the years,2 this operate has largely been neglected in favor of newer, costlier medicine. Now, groundbreaking experiments should not solely reaffirming aspirin’s potential in preventing most cancers but additionally uncovering a stronger analog that would revolutionize our strategy to most cancers therapy.
This forgotten operate of aspirin, and its much more highly effective cousin, might provide new hope within the battle towards one in all humanity’s most persistent well being challenges. Let’s discover the thrilling developments which are inflicting researchers to take a recent take a look at this acquainted drug.
Aspirin and Most cancers: Introducing 2,6-Dihydroxybenzoic Acid
In my interview with Georgi Dinkov, above, he discusses his experiments with mice utilizing a mixture of B nutritional vitamins — B1, B3 and B7 — and aspirin to fight a extremely deadly type of human mantle cell lymphoma. He discovered that whereas the nutritional vitamins alone stopped tumor progress, including aspirin at a human-equivalent dose of about 1.5 grams per day led to finish tumor regression in all three check topics.
Constructing on the success with aspirin, Dinkov launched a stronger analog of aspirin often known as 2,6-dihydroxybenzoic acid. Not solely is it a lot stronger, it’s additionally way more lipophilic, that means it has a larger affinity for lipids (fat) than water. Lipophilic compounds are typically extra simply absorbed by means of cell membranes.
Dinkov explains the theoretical foundation for utilizing this compound, which relies on reducing intracellular pH to induce most cancers cell loss of life:3
“Considered one of Ray [Peat]’s fundamental theories was that … most cancers cells … [are] metabolically dysfunctional, everyone knows that, and sometimes a cell like that commits apoptosis. However as a way to commit apoptosis, that mechanism is managed virtually fully by the intracellular pH. And to ensure that apoptosis to happen, it must be within the acidic vary.
However the most cancers cells are alkaline on account of exporting lactate and hydrogen ions. So, if something can drop the intracellular pH, these most cancers cells, as a result of they’re deranged, ought to truly disappear by themselves.
And one in all Peat’s strategies on the time was, ‘Why don’t you employ the drug acetazolamide?’ which as a carbonic anhydrase inhibitor, will increase carbon dioxide. Carbon dioxide is acidic, after which that ought to permit most cancers cells to commit apoptosis.
There are some research in vitro and in vivo displaying that acetazolamide may go, however it didn’t actually treatment the tumors. It was a slower progress, partial regression, however it confirmed that the concept was heading in the right direction.
So, I mentioned, ‘Let’s discover one thing that’s way more acidic than carbon dioxide.’ And that’s this 2,6-dihydroxybenzoic acid, which is only one additional hydroxyl group on high of aspirin. Salicylic acid, actually, which is 2-hydroxybenzoic acid. After which this factor is about 10 occasions stronger than aspirin.”
Observe-up research have yielded promising outcomes, with tumors regressing after one week. Dinkov notes that 2,6-dihydroxybenzoic acid is, “Freely accessible. No patent, nothing on it. Fairly a couple of research again within the day, however actually a really generic molecule … Grime low-cost, too. Cheaper than aspirin.”4
Simply as aspirin was developed from a pure supply (willow bark), different pure compounds, together with these derived from the leaves of the medicinal plant Lithraea molleoides,5 additionally present cytotoxic results, including to the rising physique of proof that plant-derived compounds can have vital anticancer potential. Compounds remoted from Mangifera zeylanica, a species of mango tree native to Sri Lanka, even have cytotoxic and apoptotic results.6
Aspirin-Vitamin C Mixture Treats Strong Tumors Higher Than Chemo
Whereas analysis suggests 2,6-dihydroxybenzoic acid might be a promising device towards most cancers, aspirin additionally reveals immense promise. Your physique might profit much more when aspirin is mixed with vitamin C, which additionally has antitumor results. Current research have proven that this mix could be simpler towards most cancers cells whereas remaining gentler on wholesome cells in comparison with typical chemotherapy medicine like doxorubicin.7
In laboratory exams, the aspirin-vitamin C mixture confirmed a robust cytotoxic impact on liver most cancers cells however was a lot much less dangerous to regular lung cells.8 This selectivity is essential for lowering the unwanted side effects related to most cancers remedies. The synergy between these two frequent substances seems to boost their particular person anticancer properties, providing a safer different to harsh chemotherapies.
The potential of aspirin and vitamin C extends past the lab, with encouraging ends in animal research. When examined on rats with chemically induced liver most cancers, the mix remedy confirmed outstanding outcomes.9 After 90 days of therapy, the livers of handled rats had vital enchancment in each look and performance.
Importantly, many of the liver tissue appeared regular beneath microscopic examination. This mixture remedy outperformed doxorubicin in restoring liver well being and lowering tumor markers.
Aspirin Works Synergistically with Vitamin C
In one other research, the mix of aspirin, also referred to as acetylsalicylic acid (ASA), and vitamin C, or ascorbate (AS), confirmed superior ends in shrinking tumors in comparison with both compound alone.10 When mice with strong tumors had been handled with the mix, their tumor quantity decreased by 46%, versus 40% with ASA alone and 36% with AS alone.
This synergistic impact possible stems from combining aspirin’s anti-inflammatory properties with vitamin C’s potent antioxidant capabilities. The 2 compounds seem to work collectively to create a extra hostile setting for most cancers cells, impeding their progress and proliferation.
By attacking tumors by means of a number of mechanisms concurrently, the aspirin-vitamin C mixture might overcome a few of the diversifications most cancers cells sometimes develop to evade single-compound remedies.
Past simply shrinking tumors, the aspirin-vitamin C mixture considerably prolonged survival occasions and appeared to enhance total well being within the tumor-bearing mice. Mice handled with the mix survived a mean of 93.5 days, in comparison with simply 54 days for untreated tumor-bearing mice — a 73% improve in lifespan.11
The mixture additionally outperformed both compound alone in normalizing varied biomarkers of liver, kidney and coronary heart operate that had been disrupted by the most cancers. Notably, the mix was capable of improve hemoglobin ranges, probably assuaging the anemia usually related to most cancers.
These enhancements in organ operate and blood parameters recommend the aspirin-vitamin C therapy might have wide-ranging advantages for total well being and high quality of life, past simply its antitumor results.
A key mechanism behind the aspirin-vitamin C mixture’s results seems to be its highly effective modulation of oxidative stress and irritation within the physique. The research discovered that tumor-bearing mice had considerably elevated ranges of oxidative stress markers like malondialdehyde (MDA) and nitric oxide (NO), together with depleted antioxidant defenses.
Remedy with aspirin and vitamin C dramatically reversed these imbalances, lowering MDA and NO whereas boosting whole antioxidant capability, glutathione and catalase exercise. By making a much less inflammatory, much less oxidative setting within the physique, the mix might make it tougher for most cancers cells to thrive and unfold.
This rebalancing of the redox state may have far-reaching results all through the physique, probably explaining the enhancements seen in a number of organ methods. The research’s findings underscore the significance of addressing persistent irritation and oxidative stress as a part of a complete strategy to most cancers therapy and prevention.
Aspirin’s Promising Position in Colorectal Most cancers Prevention
Aspirin can also considerably cut back the chance of colorectal most cancers (CRC), one of many main causes of cancer-related deaths worldwide. Research have proven that taking at the least 75 milligrams (mg) of aspirin each day for a number of years can lower each the incidence and mortality of CRC.12
Curiously, the helpful impact seems to be most pronounced for proximal colon cancers, that are sometimes tougher to stop by means of customary screening strategies like colonoscopy or sigmoidoscopy. Lengthy-term aspirin use, notably for over 20 years, has been related to a outstanding 35% discount in CRC incidence.13
These findings recommend that incorporating low-dose aspirin into your long-term well being technique may provide vital safety towards this frequent type of most cancers.
Past its preventive results, aspirin can also enhance outcomes for these already identified with colorectal most cancers. Analysis signifies that common aspirin use after a CRC prognosis is linked to lowered dangers of each total and CRC-specific mortality. This profit seems to be notably pronounced in tumors that overexpress cyclooxygenase-2 (COX-2).14 Furthermore, aspirin’s protecting results aren’t restricted to colorectal most cancers alone.
Research have proven that long-term aspirin use can cut back the 20-year threat of loss of life from any most cancers by 20%, with an much more substantial 35% discount in gastrointestinal most cancers deaths.15 These findings recommend that should you’re at elevated threat for most cancers or have already been identified, aspirin use might be a useful a part of your therapy and prevention technique.
Research recommend aspirin might assist suppress tumor progress, cut back metastasis and even improve the effectiveness of different most cancers remedies.16 This multi-pronged strategy makes aspirin a very promising agent within the combat towards colorectal most cancers. For people at increased threat of CRC, reminiscent of these with a historical past of colorectal neoplasia or genetic predisposition, aspirin might provide much more promise.
A scientific assessment of research involving individuals with earlier colorectal neoplasia discovered a non-statistically vital discount in superior neoplasia with low-dose aspirin use.17 Moreover, for carriers of Lynch syndrome genes, high-dose aspirin for 2 years was related to a decreased threat of colorectal most cancers.18
People with Lynch syndrome have a considerably increased lifetime threat of growing colorectal most cancers. The Nationwide Institute for Well being and Care Excellence recommends sufferers identified with Lynch Syndrome start each day aspirin remedy to cut back the chance of colorectal most cancers.19
Aspirin’s Broad Most cancers-Preventing Potential
Analyses of long-term cardiovascular trials have additionally revealed aspirin’s sudden energy in preventing most cancers throughout a number of websites.20 Research present vital reductions in deaths from esophageal and abdomen cancers amongst long-term aspirin customers, and knowledge point out it could additionally decrease your threat of lung, prostate and breast cancers.
Maybe most enjoyable is the potential for a 20% to 30% discount in total most cancers incidence after simply three to 5 years of each day low-dose aspirin use.21 Additional, research constantly present that low doses — as little as 75 mg to 100 mg each day — are simply as efficient as increased doses in lowering most cancers threat.22
The effectiveness of low-dose regimens additionally factors to a novel mechanism of motion. Quite than straight affecting tissues all through your physique, aspirin may go by inhibiting platelets, which play an important function in each early most cancers growth and later metastasis.23 Whereas some advantages of aspirin use might seem inside a couple of years, different reductions in most cancers threat emerge with long-term use.
Research monitoring individuals for 20 years or extra have discovered that aspirin’s protecting results towards gastrointestinal cancers turn out to be extra pronounced over time. For colorectal most cancers, vital reductions in incidence and mortality had been noticed 10 to twenty years after the beginning of aspirin use.24 This long-lasting impact means that aspirin could also be altering basic processes in most cancers growth, providing enduring safety towards this illness.
Aspirin’s potential as a repurposed drug for most cancers remedy is one other thrilling space of analysis.25 Aspirin works by inhibiting COX enzymes, notably COX-1 and COX-2. This mechanism not solely helps stop coronary heart assaults however can also fight most cancers in a number of methods. By inhibiting COX-1, aspirin reduces platelet aggregation round tumor cells, making these malignant cells extra seen to your immune system.26 This might assist stop most cancers from spreading all through your physique.
Moreover, aspirin’s impact on COX-2 might straight affect tumor progress. COX-2 produces prostaglandin E2, which stimulates tumor cell progress. By lowering prostaglandin E2 manufacturing, aspirin may sluggish or stop tumor growth.27
The way forward for aspirin in most cancers prevention might lie in personalised drugs. Rising analysis has recognized a number of genetic markers that would assist predict who will profit most from aspirin remedy. For instance, sure variations in genes like UGT1A6 and ALOX12 have been related to enhanced aspirin efficacy in lowering colorectal most cancers threat.28
Moreover, your expression ranges of enzymes like 15-PGDH might affect how properly you reply to aspirin’s cancer-fighting properties.29 These genetic insights open up thrilling prospects for tailoring aspirin use to your particular person genetic profile. Within the coming years, genetic testing may turn out to be a routine a part of figuring out whether or not aspirin is best for you and at what dose.
Willow Bark: Nature’s Time-Examined Ache Reliever
For these with aspirin sensitivity, salicylic acid or willow bark dietary supplements could also be alternate options value contemplating. While you devour aspirin, your physique converts the acetylsalicylic acid into salicylic acid, which is answerable for aspirin’s anti-inflammatory, analgesic and antithrombotic properties. Willow bark naturally comprises this compound.
This historic medicinal plant carries with it centuries of therapeutic knowledge, providing a compelling different to fashionable prescription drugs. Willow bark’s efficacy stems from its long-standing relationship with human physiology. In contrast to laboratory-created medicine, the energetic compounds in willow bark have been interacting with our biochemistry for hundreds of years.
This prolonged coexistence has fostered a pure compatibility that many manmade drugs wrestle to attain.
Our ancestors’ constant, albeit minimal, consumption of those compounds over generations has allowed our our bodies to develop an environment friendly technique of processing and using them. This evolutionary adaptation underscores the potential benefits of pure cures over their artificial counterparts. Additional, analysis means that a few of willow bark’s therapeutic properties are on account of synergistic results,30 providing advantages past these of salicylic acid alone.
The pharmaceutical business’s growth of aspirin within the nineteenth century marked a major shift from nature-based to laboratory-derived drugs.31 Whereas this transition led to the creation of a patentable product, it did not essentially enhance upon the unique supply materials. The truth is, the enduring recognition of willow bark serves as a testomony to the facility of plant-based cures.
For these contemplating willow bark as a substitute for aspirin, notably people with aspirin sensitivity, understanding correct dosage is vital. Whereas willow bark and aspirin share comparable energetic compounds, their metabolism and bioavailability differ, necessitating distinct dosing methods.
So, whereas 240 mg to 600 mg of willow bark extract (15% salicin) is commonly estimated to offer a salicin dose that’s roughly equal to 325 mg of aspirin, the overall quantity of willow bark extract wanted is often bigger:
- To approximate the consequences of 81 mg of aspirin, a dose of 400 mg to 800 mg of willow bark extract (standardized to fifteen% salicin) is often required.
- For results just like 111 mg of aspirin, a dose of 500 mg to 1 gram of willow bark extract (standardized to fifteen% salicin) is mostly wanted.
Ideas for Aspirin Dosage and Length
When choosing aspirin, select immediate-release formulations somewhat than coated extended-release variations to keep away from pointless components. Instant-release aspirin is out there on Amazon. Look at the inactive elements checklist fastidiously; ideally, corn starch must be the one additive listed.
After intensive analysis, I recognized a product assembly these specs. The suitable dosage ranges from 82 mg to 325 mg each day, taken along with your largest meal, relying in your particular person wants.
Based mostly on my analysis into aspirin’s preventive advantages, I personally take 111 mg each day utilizing Well being Natura’s USP grade 60 gram aspirin powder, which prices lower than $20. This 99% pure USP aspirin powder appeals to me on account of its prometabolic, antilipolytic, anti-inflammatory, anticortisol and anti-estrogen results. Its security profile is well-established.
On the subject of most cancers prevention, the dosage and length of aspirin use seem like essential components. Low doses of aspirin (75 to 300 mg/day) have been proven to be as efficient as increased doses in lowering CRC-related mortality,32 suggesting that you just need not take massive quantities to reap the potential advantages. Nevertheless, consistency and long-term use appear to be key.
Research point out that the advantages of aspirin improve with length of use, with probably the most vital reductions in most cancers threat noticed after 5 to 7.5 years of standard use.33 As analysis progresses, aspirin might show to be a robust new device in your most cancers prevention and therapy arsenal — one which’s been in your drugs cupboard all alongside.
